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Name: Huimin Ma

Title:  associate researcher, Ph.D.

Phone: 020-38350661

Email: mahuimin@gig.ac.cn

 

Huimin Ma, associate researcher, Ph.D., is engaged in the research on the early health effects of environmental pollutants. She studied the effects of atmospheric fine particles (including PM2.5 and PM0.1, etc.), heavy metals and organic compounds (benzene, triclosan, etc.) in the environment on human health. Using in vivo and in vitro experimental methods, she screened the effective toxic components of atmospheric particles, the effects of heavy metals on human health objective, the specific biomarkers of environmental organic pollutants on human body, and tried to elaborate the toxic mode on human body.

Aiming at the problem of heavy metal pollution in the environment, the intelligence of school-age children in a heavy metal polluted area in Guangzhou was tested. Combined with the level data of four heavy metals in children's blood and urine, it was found that there was a significant joint effect between the four heavy metals, in which blood lead was still the main factor inducing children's mental decline. Combined with in vitro experiments, two DNA methylation biomarkers of imprinting genes were selected. The results showed that when the blood lead level was lower than the national detection line of 100 μ g / L (about 57 μ g / L), there was still a significant negative correlation between the blood lead and intelligence, suggesting that the national government departments need to re-examine the relevant safety standards of blood lead. The conclusion was published in ES & T and EP journals.

 Regarding the screening the toxicity components in PM2.5, the results showed that humic like substances (HULIS) in PM2.5 may be the main toxic component in inducing inflammation and apoptosis. Cell model was used to detect toxicity, Fourier transform ion cyclotron resonance mass spectrometry was used to analyze the composition of compounds, accelerator mass spectrometry was used to analyze the source information of different pollutants, nuclear magnetic resonance was used to explore the structure information of organic compounds, and preparative liquid chromatography was used to separate different compounds. It is revealed that the HULIS component in atmospheric particulate matter may be one of the main components of water-soluble components of particulate matter that induce inflammation and apoptosis. Among them, oxygen-containing groups, aromatic rings and double bond structures contribute greatly to inflammation and apoptosis. These compounds may be related to biomass combustion such as corn stalk, traffic source emissions and coal-fired emissions. The panel study was carried out, and the samples of the group were collected to analyze the damage of PM2.5/PM0.1 exposure to human heart and lung function, the harm of each component of particulate matter to health and its contribution, and the toxic mechanism of each component. The results were published in ES & T and EP and selected as the supplementary cover.

She firstly established HPLC-MS / MS method to detect the whole genome DNA methylation in China. The toxic effects induced by low concentration exposure of triclosan, benzene and their metabolites were analyzed, and potential molecular markers were screened. The article on triclosan was published in toxicology in vitro and chemistry, and was recommended as "very good" by F1000prime, a well-known British literature recommendation platform. The contribution of the results of the paper to the hepatotoxicity of triclosan was evaluated.

Study and work:

1999-2003: Anhui Medical University, biotechnology, bachelor's degree;

2003-2009: Guangzhou Institute of geochemistry, Chinese Academy of Sciences, Ph.D;

2007-2008: Jacobs University, Germany, biochemistry, cooperation doctoral candidate;

2009 – 2011: Assistant Researcher, State Key Laboratory of organic geochemistry, Guangzhou Institute of geochemistry, Chinese Academy of Sciences;

2011 – present: State Key Laboratory of organic geochemistry, Guangzhou Institute of geochemistry, Chinese Academy of Sciences; associate researcher;

2018 – 2019：Lancaster Environmental Center, Lancaster University, Lancaster UK, Visiting Scholar.

Research Interests：

Recent Publications：

[1].Qianyu Zhang, Huimin Ma*, Jun Li*, Hongxing Jiang, Wenjing Chena, Cong Wan, Bin Jiang, Guanghui Dong, Xiaowen Zeng, Duohong Chen, Shaoyou Lu, Jing You, Zhiqiang Yu, Xinming Wang, Gan Zhang, Nitroaromatic compounds from secondary nitrate formation and biomass burning are major pro-inflammatory components in organic aerosols in Guangzhou: a bioassay combining high-resolution mass spectrometry analysis, Environmental Science& Technology, 2023, https://doi.org/10.1021/acs.est.3c04983 . (IP=11.4)（内封面文章）

[2].Cong Wan , Huimin Ma*, Jiahong Liu , Fei Liu, Jing Liu, Guanghui Dong, Xiaowen Zeng, Daochuan Li, Zhiqiang Yu , Xinming Wang, Jun Li, Gan Zhang, Environ. Quantitative relationships of FAM50B and PTCHD3 methylation with reduced intelligence quotients in school aged children exposed to lead: Evidence from epidemiological and in vitro studies. Science Of The Total Environment, 2023.167976, https://doi.org/10.1016/j.scitotenv.2023.167976.  (IP=10.75)

[3].Huimin Ma*, Wenjing Chen, Qianyu Zhang, Cong Wan, Yangzhi Mo, Fei Liu, Guanghui Dong, Xiaowen Zeng, Duohong Chen, Zhiqiang Yu, Jun Li, Gan Zhang. Pollution source and chemicals structure of the water-soluble fractions in PM2.5 that induce apoptosis in China, Environment International, 173:107820, https://doi.org/10.1016/j.envint.2023.107820 (IP=11.8)

[4].Patent：A set of biomarkers for detecting lead induced mental decline in children and its application, Application No：202211231474.8;

[5].Cong Wan, Shangxia Pan, Lifeng Lin, Jun Li, Guanghui Dong, Kevin C. Jones, Fei Liu, Daochuan Li, Jing Liu, Zhiqiang Yu, Gan Zhang, and Huimin Ma*, DNA Methylation Biomarkers of IQ Reduction are Associated with Long Term Lead Exposure in School Aged Children in Southern China . Environmental Science& Technology, 2021, 55(1): 412–422, http://dx.doi.org/10.1021/acs.est. 0c01696;  (IP=11.4)

[6].Yaohui Liang, Liwen Hu, Jun Li, Fei Liu, Kevin C. Jones, Daochuan Li, Jing Liu, Duohong Chen, Jing You, Zhiqiang Yu, Gan Zhang, Guanghui Dong, Huimin Ma*, Short-term personal PM2.5 exposure and change in DNA methylation of imprinted genes: Panel study of healthy young adults in Guangzhou city, China, Environmental Pollution, 2021,15(275):116601, doi: 10.1016/j.envpol.2021. 116601.(IP=8.9)

[7].Huimin Ma, Jun Li, Cong Wan, Yaohui Liang, Xiangyun Zhang, Guanghui Dong, Liwen Hu, Boyi Yang, Xiaowen Zeng, Tao Su, Shaoyou Lu, Shejun Chen, Mahdi Safaei Khorram, Guoying Sheng, Xinming Wang, Bixian Mai, Zhiqiang Yu*, Gan Zhang*， Inflammation response of water-soluble fractions in atmospheric fine particulates: a seasonal observation in 10 large Chinese cities， Environmental Science& Technology. 2019, 53(7):3782-3790. (IP=11.4) （内封面文章）

[8].Shangxia Pan, Lifeng Lin, Fan Zeng, Jianpeng Zhang, Guanghui Dong, Boyi Yang, You Jing, Shejun Chen, Gan Zhang, Zhiqiang Yu, Guoying Sheng, Huimin Ma*, Effects of lead, cadmium, arsenic, and mercury co-exposure on children's intelligence quotient in an industrialized area of southern China, Environmental Pollution, 2018, 20(235):47-54. (IP=8.9)

[9].Liudan Zeng, Huimin Ma*, Shangxia Pan, Jing You, Gan Zhang, Zhiqing Yu,  Guoying Sheng, Jiamo Fu，LINE-1 gene hypomethylation and p16 gene hypermethylation in HepG2 cells induced by low-dose and long-term Triclosan exposure: The role of hydroxyl group, Toxicology in vitro, 2016，34:35-44. (IP=3.2)

[10].Junjie Hu, Huimin Ma*, Wenbing Zhang*, Zhiqing Yu, Guoying Sheng, Jiamo Fu，Effects of benzene and its metabolites on global DNA methylation in human normal hepatic L02 cells, Environmental Toxicology. 2014, 29:108-116. (IP=4.35)

[11].Huimin Ma*, Liujin Zheng, Yuhua Li, Shaxia Pan, Zhiqiang Yu, Gan Zhang, Guoying Sheng, Jiamo Fu，Triclosan Reduces the Levels of Global DNA Methylation in HepG2 Cells，Chemosphere, 2013,90:1023-1029. (IP=7.09)

[12].Junjie Hu, Wenbing Zhang*, Huimin Ma*, Yunmei Cai, Guoying Sheng, Jiamo Fu.Simultaneous determination of 8-hydroxy-2 '-deoxyguanosine and 5-methyl-2 '-deoxycytidine in DNA sample by highperformance liquid chromatography/positive electrospray ionization tandem mass spectrometry. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 2010, 878:2765-2769.  (IP=3.21)

[13].Huimin Ma, Wenbing Zhang*, Junjie Hu, Zhiqiang Yu, Yong Chen, Qiong luo, Xiaoliu Shi, Yingying Zhang, Renfang Song, Zhen Zhou, Guoying Sheng and Jiamo Fu, “Analysis of global DNA methylation level in human blood using high-performance liquid chromatography/tandem electrospray ionization mass spectrometry (HPLC-ESI-MS/MS)”, European Journal of Mass Spectrometry, 2009,15: 555-561.  (IP=1.3)

[14].Huimin Ma， Wenbing Zhang*， Renfang Song， Huayong Chen， Guoying Sheng， Zhen Zhou and Jiamo Fu, “Characterization of methylated and unmethlyated CpG oligodeoxynucleotides by electrospray ionization tandem mass spectrometry”, European Journal of Mass Spectrometry, 2005,11：581-589；(IP=1.3)

[15].刘家宏，万 聪，潘尚霞 , 马慧敏*，某工业区诱导儿童神经损伤的关键重金属及暴露途径，地球化学，2024，已接收

[16].潘尚霞，马慧敏*，林立丰，张建鹏，万聪，环境铅暴露对儿童智力和精神运动功能影响研究，华南预防医学，2017，5：412-417。

[17].曾柳丹，马慧敏,*, 张干, 于志强, 盛国英，傅家谟， BDE-208和BDE-209诱导了LINE-1基因低甲基化和ESR1基因高甲基化,生态毒理学报，2016，2：163-169。

[18].王晶晶、马慧敏*、李宝才*、郑刘进、潘尚霞、黎玉华、盛国英、傅家谟，苯代谢物氢醌对人体肝细胞内DNA甲基转移酶基因和蛋白表达的影响 ，昆明理工大学学报(自然科学版), 2013,38:90-95.

[19].胡俊杰、马慧敏*、张文兵、李林朋、于志强、盛国英、傅家谟，苯急性暴露对Sprague-Dawley大鼠全基因组DNA 甲基化的影响，生态环境学报,2010, 19(12):2902-2905.

[20].马慧敏，张文兵*，施小六，于志强，胡俊杰，宋任芳，盛国英，傅家谟, “人体结肠癌组织样品中基因组DNA甲基化水平的HPLC-ESI-MS/MS检测”，分析测试学报, 2009, 5:292-296.

[21].Yang B, Qian Z, Vaughn M, Nelson E, Dharmage S, Heinrich J, Lin S, Lawrence WR, Ma H, Chen D, Hu L, Zeng X, Xu S, Zhang C, Dong G. Is prehypertension more strongly associated with long-term ambient air pollution exposure than hypertension? Findings from the 33 Communities Chinese Health Study. Environmental Pollution. 2017;229:696-704.

[22]. Philipp Rathert, Arunkumar Dhayalan, Huimin Ma and Albert Jeltsch*， “Specificity of protein lysine methyltransferases and methods for detection of lysine methylation of non-histone proteins” Moecular. BioSystems, 2008，4：1186 – 1190；

[23].Renfang Song， Wenbing Zhang， Huayong Chen， Huimin Ma， Yulian Dong， Guoying Sheng， Zhen Zhou and Jiamo Fu*，“Characterization of G-rich and T-rich oligonucleotides using ion-pair reversed-phase high-performance liquid chromatography/tandem electrospray ionization mass spectrometry”， European Journal of Mass Spectrometry, 2004，10：705-713。

[24]. Renfang Song， Wenbing Zhang， Huayong Chen，Huimin Ma，Yulian Dong， Guoying Sheng， Zhen Zhou and Jiamo Fu*, “Comparison of A+T rich oligonucleotides with and without self-complementary sequence using ion-pair reversed-phase high-performance liquid chromatography/tandem electrospray ionization mass spectrometry”， European Journal of Mass Spectrometry，2005, 11：83-92

[25]. Huayong Chen， Wenbing Zhang，Renfang Song，Huimin Ma，Yulian Dong， Guoying Sheng， Zhen Zhou and Jiamo Fu*, “Analysis of DNA methylation by ion-pair reversed-phase high-performance liquid chromatography/tandem electrospray ionization mass spectrometry”， Rapid Communications in Mass Spectrometry , 2004, 18：2773-2778

[26]. Renfang Song， Wenbing Zhang， Huayong Chen，Huimin Ma，Yulian Dong， Guoying Sheng， Zhen Zhou and Jiamo Fu*, “Site determination of phenyl glycidyl ether-DNA adducts using high-performance liquid chromatography tandem electrospray ionization mass spectrometry”， Rapid Communications in Mass Spectrometry , 2005, 19: 1120-1124

[27]. Renfang Song， Wenbing Zhang，Huayong Chen，Huimin Ma，Yulian Dong， Guoying Sheng， Zhen Zhou and Jiamo Fu*，“Analysis of SNPs sites in exon 4 of the P53 gene using high-performance liquid chromatography electrospray ionization mass spectrometry tandem mass spectrometry”, European Journal of Mass Spectrometry , 2006, 12: 205-211

[28]. Renfang Song， Wenbing Zhang， Huayong Chen，Huimin Ma，Yulian Dong, Guoying Sheng， Zhen Zhou and Jiamo Fu*，“Characterization of activation energy distribution for UV irradiation of T-rich oligonucleotide using high-performance liquid chromatography electrospray ionization mass spectrometry tandem mass spectrometry”, European Journal of Mass Spectrometry, 2006, 12 :283-289


Projects:

(1)     National Natural Science General Project, project name: "Screening of Toxic Pollutants in Air Particulate Matter and Study of Their Major Sources Based on a Fixed Panel Population Experiment", from January 2025 to December 2028, funding 470000RMB, Project No.: 42477257, Project Leader;

(2)     National Natural Science General Project, project name: "screening and identification of effective toxic components of humic acid like compounds in atmospheric fine particles", from January 2021 to December 2024, funding 570000RMB, Project No.: 42077197, Project Leader;

(3)     State key R & D program, national cooperation project, key technology and application of traffic source ultrafine particle exposure and neurodegenerative disease risk assessment, 2018YFE0106900, from July 2019 to July 2022 to 65.7 million, the third project leader;

(4)     Guangdong Provincial Natural Science Foundation, general project, 2019a1515011859, preliminary identification of DNA methylation biomarkers of blood lead induced mental retardation in children, from October 2019 to September 2022, 100000RMB, Project Leader;

(5)     Guangzhou Science and technology plan project, project name: "toxic contribution of humic acid like compounds from different sources in PM2.5 of Guangzhou city to human lung cells", March 2021 - March 2023, funding: 50000RMB, Project Leader.

(6)     National fund key project, project name "distribution and evolution of chemical composition and toxicity of polycyclic aromatic organic matter (POM) in atmospheric particulates", from January 2021 to December 2025, funding: 3.04 million RMB, project number: 42030715, main participants;

(7)     The key project of scientific research of Guangzhou Science and technology plan, 2017020033, toxic organic compounds and toxic effects of atmospheric particulates in different typical areas of Guangzhou, from May 2017 to December 2020, 2 million RMB, main participants;

(8)     National Natural Science Youth Foundation, 21007072, HPLC-MS / MS internal standard method to study the effect of typical pollutants on human DNA methylation, 2011-1 to 2013-12, 190000 RMB, Project Leader;

(9)     Key direction project of knowledge innovation project of Chinese Academy of Sciences, kzcx2-yw-gj02, pops pollution and its Cross-border Migration Trend in South Asia, 1.9 millionRMB from January 2010 to January 2012, Project Leader of the second topic ;

(10) The frontier project in the field of knowledge innovation, Guangzhou Institute of geochemistry, Chinese Academy of Sciences, gigcx-09-01, effects of benzene and its metabolites on gene methylation of human liver and bone marrow cells, 2009-11 to 2011-11, 200000 RMB, Project Leader.
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